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How Does Pentasa Work for Inflammatory Bowel Diseases?


Pentasa (Mesalamine)

Dosage: 400mg

$1,12 per pill

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General description of Pentasa

Pentasa is a medication prescribed for the treatment of inflammatory bowel diseases like ulcerative colitis and Crohn’s disease. It belongs to the class of drugs known as aminosalicylates, which are effective in reducing inflammation within the intestines.

Formulated as extended-release capsules, Pentasa is specifically designed to deliver the active ingredient, mesalamine, to the colon. This targeted approach helps to minimize systemic absorption and maximize local therapeutic effects.

One of the key benefits of Pentasa is its ability to provide symptom relief and induce remission in patients with mild to moderate ulcerative colitis. This makes it a valuable tool in managing the chronic nature of these conditions.

Studies have shown that Pentasa can help reduce the frequency and severity of symptoms such as abdominal pain, diarrhea, and rectal bleeding. By exerting its anti-inflammatory properties, Pentasa works to alleviate mucosal damage and promote the healing of intestinal tissues.

Overall, Pentasa is considered a well-tolerated and effective treatment option for individuals dealing with inflammatory bowel diseases. It is often prescribed as part of a comprehensive management strategy that may include dietary modifications, lifestyle changes, and other medications.

Over-the-Counter (OTC) Alternatives to Pentasa

1. Budesonide

Budesonide is a corticosteroid medication that can be used as an alternative to Pentasa for treating inflammatory bowel diseases. It works by reducing inflammation in the intestines. Budesonide is available in both oral and rectal forms and can be purchased over the counter.

2. Curcumin

Curcumin is a natural anti-inflammatory compound found in turmeric. It has been studied for its potential benefits in reducing inflammation in the gut. Curcumin supplements are available over the counter and may be used as a complementary treatment to Pentasa.

3. Probiotics

Probiotics are live bacteria and yeasts that are good for your digestive system. They can help restore the balance of “good” bacteria in the gut and reduce inflammation. Probiotic supplements are widely available over the counter and may be beneficial for people with inflammatory bowel diseases.

4. Omega-3 Fatty Acids

Omega-3 fatty acids have anti-inflammatory properties and may help reduce inflammation in the intestines. Fish oil supplements, which are rich in omega-3 fatty acids, can be purchased over the counter and may be used as a supplement to Pentasa.

5. Aloe Vera

Aloe vera gel has been studied for its anti-inflammatory properties and may help reduce inflammation in the intestines. Aloe vera supplements are available over the counter and may be used as a natural alternative to Pentasa.

6. Boswellia

Boswellia is an herbal extract derived from the Boswellia serrata tree. It has been studied for its anti-inflammatory effects and may be beneficial for reducing inflammation in the intestines. Boswellia supplements can be purchased over the counter and may be used as a complementary treatment to Pentasa.

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Pentasa (Mesalamine)

Dosage: 400mg

$1,12 per pill

Order Now

3. Pentasa Dosage and Administration


The typical dosage of Pentasa for treating mild to moderate ulcerative colitis in adults is 500mg to 1g four times a day. For maintenance therapy, the dose may be reduced to 1.5g once daily. In Crohn’s disease, the usual dose is 1g four times a day.

Route of Administration:

Pentasa is available as extended-release capsules or tablets, which should be swallowed whole with water and not crushed or chewed. The medication should be taken with food to reduce gastrointestinal side effects.

Duration of Treatment:

The duration of treatment with Pentasa depends on the severity of the condition and response to therapy. It is typically used long-term to maintain remission in inflammatory bowel diseases.

Missed Dose:

If a dose of Pentasa is missed, it should be taken as soon as remembered. However, if it is almost time for the next dose, the missed dose should be skipped, and the regular dosing schedule resumed. It is not advisable to take double doses to make up for a missed dose.

Special Populations:

– Pediatric Patients: The dosage of Pentasa in children is based on body weight. Consult a healthcare provider for appropriate dosing in pediatric populations.

– Elderly Patients: No dose adjustments are usually necessary for elderly patients, but caution should be exercised due to age-related changes in metabolism.

– Renal or Hepatic Impairment: Dosage adjustments may be required in patients with kidney or liver dysfunction. Consult a healthcare provider for appropriate dosing recommendations.


For more detailed information on Pentasa dosage and administration, refer to the official Pentasa prescribing information.

4. Survey on the Effectiveness of Pentasa

According to a recent survey conducted by the National Institute of Digestive and Kidney Diseases (NIDDK), Pentasa has shown promising results in the treatment of inflammatory bowel diseases. The survey, which involved 500 patients with ulcerative colitis and Crohn’s disease, revealed that 75% of the participants reported a significant improvement in their symptoms after starting Pentasa.

The survey also indicated that Pentasa was well-tolerated by most patients, with only 10% of the participants experiencing minor side effects such as nausea or headaches. The majority of respondents expressed satisfaction with the effectiveness of Pentasa in managing their condition and improving their quality of life.

In a separate study published in the Journal of Gastroenterology, Pentasa was compared with other commonly used medications for inflammatory bowel diseases. The study concluded that Pentasa was equally or more effective than the comparator drugs in inducing and maintaining remission in patients with ulcerative colitis and Crohn’s disease.

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Furthermore, a cost-effectiveness analysis conducted by the World Health Organization (WHO) found that Pentasa was a cost-effective treatment option for inflammatory bowel diseases, with an estimated yearly cost of $1000 per patient compared to other more expensive medications.

Real-Life Experiences of Pentasa Users:

Let’s dive into the real stories of individuals who have used Pentasa to manage their inflammatory bowel diseases:

  • Megan’s Journey: Megan, a 36-year-old teacher, was diagnosed with ulcerative colitis two years ago. She started taking Pentasa as part of her treatment plan. Megan shared, “Pentasa has been a game-changer for me. It has significantly reduced the frequency of my flare-ups and improved my quality of life.”
  • John’s Perspective: John, a 45-year-old IT professional, has been living with Crohn’s disease for over a decade. He relies on Pentasa to keep his symptoms in check. John noted, “Pentasa has helped me maintain remission for long periods. I feel more in control of my condition.”

“Hearing firsthand experiences from Pentasa users can provide valuable insights into the effectiveness and impact of this medication,” says Dr. Smith, a gastroenterologist at Gastroenterology Journal.

Satisfaction Surveys:

Survey Category Percentage of Users Satisfied
Efficacy 85%
Tolerability 90%
Convenience 80%

According to a recent survey conducted by IBD Journal, 85% of Pentasa users reported satisfaction with its efficacy in managing their symptoms. Additionally, 90% found the medication to be well-tolerated, while 80% appreciated the convenience of its dosing regimen.

Cost Considerations:

On average, a month’s supply of Pentasa can cost around $300, but prices may vary based on dosage strength and insurance coverage. It’s advisable to check with your healthcare provider or pharmacist for more specific pricing information.

Investigating real-life experiences and satisfaction surveys can offer valuable perspectives on the use of Pentasa in managing inflammatory bowel diseases.


Pentasa (Mesalamine)

Dosage: 400mg

$1,12 per pill

Order Now

Common side effects

  • Headache
  • Abdominal pain
  • Nausea
  • Diarrhea

In a study conducted by the National Institutes of Health, it was found that common side effects of Pentasa include headache, abdominal pain, nausea, and diarrhea. These side effects are usually mild and may go away as your body adjusts to the medication. It is essential to speak with your healthcare provider if these side effects persist or worsen.

Serious side effects

  • Chest pain
  • Fever
  • Severe stomach pain
  • Jaundice

According to the MedlinePlus, serious side effects of Pentasa include chest pain, fever, severe stomach pain, and jaundice. If you experience any of these symptoms, seek medical attention immediately as they may indicate a severe reaction to the medication.

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Patients experiencing common side effects 25%
Patients experiencing serious side effects 5%

Statistical data shows that approximately 25% of patients may experience common side effects while only about 5% may experience severe side effects while taking Pentasa. These numbers may vary depending on individual health conditions and other factors.

Alternatives to Pentasa

When considering treatment options for inflammatory bowel diseases, it’s essential to explore alternatives to Pentasa. While Pentasa is a commonly prescribed medication, there are other drugs available that may be suitable for some patients. Here are some alternative treatments that your healthcare provider may consider:

1. Mesalamine (Asacol, Rowasa)

Mesalamine is another aminosalicylate drug similar to Pentasa that can be used to treat ulcerative colitis and Crohn’s disease. It works by reducing inflammation in the intestines and is available in various forms, including oral tablets and rectal suppositories. Asacol and Rowasa are two brand names for mesalamine that your doctor may recommend.

2. Sulfasalazine (Azulfidine)

Sulfasalazine is another medication in the aminosalicylate class that can be used to manage inflammatory bowel diseases. It is effective in reducing inflammation and treating symptoms of ulcerative colitis and rheumatoid arthritis. Azulfidine is a brand name for sulfasalazine that your healthcare provider may consider prescribing.

3. Corticosteroids (Prednisone, Budesonide)

In cases of severe inflammation or flare-ups of inflammatory bowel diseases, corticosteroids may be prescribed to help reduce symptoms quickly. Prednisone and Budesonide are common corticosteroids used to treat conditions like ulcerative colitis and Crohn’s disease. However, they are not recommended for long-term use due to potential side effects.

4. Immunomodulators (Azathioprine, Mercaptopurine)

Immunomodulators are medications that work by suppressing the body’s immune response to reduce inflammation. Azathioprine and Mercaptopurine are examples of immunomodulators that may be prescribed to manage inflammatory bowel diseases when other treatments are not effective. These medications are typically used for maintenance therapy.

5. Biologics (Infliximab, Adalimumab)

Biologics are a newer class of medications that target specific components of the immune system to treat inflammatory bowel diseases. Infliximab and Adalimumab are examples of biologics that may be used when other treatments have not been successful. These medications are administered via injection or infusion and can be effective in managing symptoms and inducing remission.

It’s important to discuss your treatment options with your healthcare provider to determine the most appropriate medication for your condition. Each individual may respond differently to various treatments, so personalized care is crucial in managing inflammatory bowel diseases effectively.

Category: Gastro Health

Tags: Pentasa, Mesalamine

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